Detecting functional modules in the yeast protein–protein interaction network
نویسندگان
چکیده
منابع مشابه
Detecting functional modules in the yeast protein-protein interaction network
MOTIVATION Identification of functional modules in protein interaction networks is a first step in understanding the organization and dynamics of cell functions. To ensure that the identified modules are biologically meaningful, network-partitioning algorithms should take into account not only topological features but also functional relationships, and identified modules should be rigorously va...
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Comprehensive data of protein interactions are suitable for large-scale identifications of functional units such as protein complexes and pathways. There have been the preceding studies to identify the functional units mainly by graph approaches and by co-expression. In this poster presentation, we propose the evolutionary approaches to identify the functional units in yeast protein interaction...
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Identifying functional modules is believed to reveal most cellular processes. There have been many computational approaches to investigate the underlying biological structures [9, 4, 10, 6]. A spectral clustering method plays a critical role identifying functional modules in a yeast protein-protein network in [6, 4]. We present an unweighted-graph version of a multilevel spectral algorithm whic...
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15 صفحه اولFunctional evolution of the yeast protein interaction network.
Protein interactions are central to most biological processes. We investigated the dynamics of emergence of the protein interaction network of Saccharomyces cerevisiae by mapping origins of proteins on an evolutionary tree. We demonstrate that evolutionary periods are characterized by distinct connectivity levels of the emerging proteins. We found that the most-connected group of proteins dates...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2006
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btl370